National Institute of Cholera and Enteric Diseases

Indian Council of Medical Research
Department of Health Research, Ministry of Health and Family Welfare, Government of India

NICED : Scientists

Dr./Sushmita Bhattacharya

Dr. Sushmita Bhattacharya

 

General Information
Name Dr. Sushmita Bhattacharya
Designation Scientist B
Date of joining ICMR 1st Nov 2017
Date of joining present post 1st Nov 2017
Discipline Biochemistry
Division  
Specialization  
Email : durgasushmita @gmail.com; sushmita.bh@icmr.gov.in
Academic Qualification:  
Graduation BSc. (Botany Hons.) - Lady Brabourne College, Kolkata
Post Graduation MSc. (Botany) - Banaras Hindu University
Doctoral Ph.D. in Science (Zoology) Therapeutic Intervention of Diabetesmellitus : Chemical and Herbal Approaches; Visva Bharati University

Profile

Research Experience

My vision of research is always oriented in doing meaningful work that will benefit mankind. During my PhD, I worked in the field of diabetes which have major impact in human health worldwide. Potential herbal antidiabetic compounds were isolated and characterized. One of the compounds was daidzein which is a novel target for inhibiting NFB transcription. Another important investigation was an interesting chemically synthesized anti-diabetic compound which acts as an insulin mimetic. Apart from this therapeutic approach, I have worked on mechanism of insulin resistance. A novel target of NFB which is induced by lipid has been studied known as Fetuin-A. In my postdoctoral research, I investigated the role of cancer associated mutations in BAP1 protein which is a major tumor suppressor. Mutations in BAP1 lead to protein aggregation which is a new concept of BAP1 protein function. I worked as a visiting scientist in UQCCR, Brisbane, Australia for four months on the aspect of oxidative stress in neurological disorders..

Research Interests

Research in my lab will be broadly directed towards understanding of host pathogen interaction and its therapeutic approach.Enteric pathogens cause cholera and severe gastric diseases. Disease develops as a result of a complex cascade of events from autophagic disruption to inflammation when infected by a pathogen. Our bacterial model will be drug resistant bacteria which can evade autophagic machinery for infiltration in host cells. Investigating the molecular mechanism behind pathogenesis will help us to develop novel therapeutics. We will use natural inhibitors from plant sources to inhibit the regulatory networks behind pathogenesis. Overarching goal of my lab is to combat cholera and gastric diseases using pharmacological sources as inhibitors.

Travel to foreign countries to attend conference/ meetings

  1. Visiting Scientist, UQCCR, Brisbane, Australia September-December 2015.

Publications

2017

  1. Mukherjee S, Chattopadhyay M, Bhattacharya S, Dasgupta S, Hussain S, Bharadwaj SK, Talukdar D, Usmani A, Pradhan BS, Majumdar SS, Chattopadhyay P, Mukhopadhyay S, Maity TK, Chaudhuri MK, Bhattacharya S A Small Insulinomimetic Molecule Also Improves Insulin Sensitivity in Diabetic Mice. PLoS One. 2017 Jan 10;12(1):e0169809. (Joint First author)  Pubmed
  2. Hanpude P, Bhattacharya S, Kumar Singh A, Maiti TK. Ubiquitin Recognition of BAP1: Understanding its Enzymatic Function" Biosci Rep. 2017 Oct 27;37(5). pii: BSR20171099.  Pubmed

2015

  1. Bhattacharya S, Hanpude P, Maiti TK. Cancer associated missense mutations in the BAP1 catalytic domain induce amyloidogenic aggregation: A new insight in enzymatic inactivation. NatureSci. Reports 2015 Dec. 18 5:18462. Pubmed
  2. Hanpude P, Bhattacharya S, DeyAK and Maiti TK. Deubiquitinating Enzymes in Cellular signaling and Diseases regulation. IUBMB Life. 2015 Jul;67(7):544-55. Review.   Pubmed

2012

  1. Seal S, Chatterjee P, Bhattacharya S, Pal D, Dasgupta S, Kundu R, Mukherjee S, Bhattacharya S, Bhuyan M, Bhattacharyya PR, Baishya G, Barua NC, Baruah PK, Rao PG, Bhattacharya S.Vapor of volatile oils from Litseacubeba seed induces apoptosis and causes cell cycle arrest in lung cancer cells. PLoSOne. 2012;7(10):e47014 Pubmed
  2. Bhattacharya S, Kundu R, Dasgupta S and Bhattacharya S Mechanism of lipidinduced insulin resistance: an Overview. Endocrinology and Metabolism2012 27(1): 12-19

2011

  1. Kundu R, Dasgupta S, Biswas A, Bhattacharya S, Pal BC, Bhattacharya S, Rao PG, Barua NC, Bordoloi M, Bhattacharya S. Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression. BiochemPharmacol. 2011 Nov 1;82(9):1186-97.   Pubmed
  2. Dasgupta S, Bhattacharya S, Maitra S, Pal D, Majumdar SS, Datta A, Bhattacharya S. Mechanism of lipid induced insulin resistance: Activated PKCε is a key regulator. BiochimBiophysActa. 2011 Apr;1812(4):495-506. Pubmed

2010

  1. Dasgupta S, Bhattacharya S, Biswas A, Majumdar SS, Mukhopadhyay S, Ray S, Bhattacharya S. NF-κB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance. Biochem J. 2010 Aug 1;429(3):451-62. (Joint first author)  Pubmed
  2. Biswas A, BhattacharyaS, Dasgupta S, Kundu R, Roy SS, Pal BC, Bhattacharya S. Insulin resistance due to lipid induced signaling defects could be prevented by mahanine. Mol Cell Biochem. 2010 Mar;336(1-2):97-107. Pubmed

2009

  1. Barma P, Bhattacharya S, Bhattacharya A, Kundu R, Dasgupta S, Biswas A, Bhattacharya S, Roy SS, Bhattacharya S. Lipid induced overexpression of NFkB in skeletal muscle cells is linked to insulin resistance. BiochimBiophysActa. 2009 Mar;1792(3):190-200. (Joint first author)  Pubmed

Patents

  1. Insulin mimetic active comprising oxodiperoxovanadates and pharmaceuticalcomposition obtained thereof. 2012. M. K. Chaudhuri, S. Hussain, S. Bharadwaj, U. B.Sinha, D. Talukdar, S. S. Majumdar, S. Subeer, S. Bhattacharya, S. Dasgupta, R. Kunduand S. Bhattacharya International Application No.: PCT/IN2011/000386; PublicationNo.: WO/2012/131689
  2. Method for inhibition of NF-κB gene expression; 2011. S. Bhattacharya, Suman Dasgupta, Pomy Barma, et.al. International Application No.: PCT/IB2011/001580; Publication No.: WO/2012/004653
  3. A synergistic pharmaceutical composition useful for the treatment of lung cancer. 2014 Publication No. WO2014002104 A1 Mantu BHUYAN, Pranab Ram BHATTACHARYYA, Pranab Kumar BARUAH, Nabin Chandra Barua, Paruchuri Gangadhar Rao, Sushmita Bhattacharya, Rakesh KUNDU, Priyajit CHATTERJEE, Soma SEAL, Sandeep Mukherjee, Suman Dasgupta, Sudipta MOITRA, Shelley Bhattacharya, Samir Bhattacharya

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