National Institute of Cholera and Enteric Diseases

Indian Council of Medical Research
Department of Health Research, Ministry of Health and Family Welfare, Government of India
WHO Collaborating Centre for Research and Training on Diarrhoeal Diseases

NICED : Scientists

Dr. Santasabuj Das

Dr. Santasabuj Das

Dr Santasabuj Das is currently appointed as Scientist E at the National Institute of Cholera and Enteric Diseases (NICED), Kolkata. He is also the principal investigator and coordinator of the Biomedical Informatics Center of ICMR at NICED. He has the academic and professional background in Clinical Medicine and is pursuing a full-time research career since 1998. He joined NICED as an independent investigator and a permanent employee in January 2005. His current research interest spans several areas of host responses to microorganisms (both pathogens and commensals) including immune responses and vaccine development. The major focus of his research is the pathogenesis of human Salmonella infections, development of subunit and conjugate vaccines against Salmonella Typhi and Paratyphi and the regulation of mucosal immune responses at the intestine during homeostasis as well as under disease conditions, such as intestinal infections and inflammatory bowel diseases. Dr Das extensively uses computational tools, in vitro and in vivo techniques and clinical materials to address his research questions. His laboratory has developed a novel mouse model of Salmonella Typhi infection. Using this model, his research has identified several virulence factors critical for the pathogenesis of Salmonella Typhi and developed a candidate subunit vaccine. His research has unearthed a number of novel signalling mechanisms that underlie pro-apoptotic and anti-cancer role of dietary fibres and regulate intestinal innate immune responses by regulating the expression of Toll-like receptors and small cationic antimicrobial peptides. His research has been funded by extramural grants from all the major funding agencies of the country (ICMR, DBT, CSIR, DST, DHR) as well as the Ministry of Education, Culture, Sports, Science and Technology of Japan and Japan Agency for Medical Research and Development. Dr Das has published 43 original research articles and 3 review articles in reputed international journals, 2 book-chapters and one WHO Module. His innovative research has been granted 2 international and one national patents. In recognition of his seminal contribution to the biomedical and health science research, he has been awarded the National Bioscience Award for Career Development, 2011 by the Department of Biotechnology, Government of India and Fulbright-Nehru Senior Research Fellowship, 2012. He is also an elected member of the West Bengal Academy of Science and Technology.

General Information
Name Dr. Santasabuj Das
Educational Qualification M.D. (General Medicine)
Designation Scientist E
Division Clinical Medicine
Specialization Molecular immunology and signal transduction
Date of joining ICMR 28th January 2005
Email : dasss@icmr.org.in

Profile

Professional Experience

Dr Santasabuj Das is a medical graduate from the University of Calcutta, Kolkata (MBBS, 1989). He completed his post-graduation from the same university (MD, General Medicine, 1996).
Worked briefly at the Division of Cellular Immunology, CSIR-Indian Institute of Chemical Biology, Kolkata as a Research Associate and then at the Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow as a Senior Resident.

Worked as a Visiting Postdoctoral Fellow at the National Center for Biological Sciences (NCBS), Bangalore from 1998-2000. The area of his research was Notch signaling in cervical cancer.
Joined the laboratory of Dr. Philip N Tsichlis, Director of Basic Sciences, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA as a Postdoctoral Fellow in the year 2000. There he worked on transcriptional regulation of MHC class II genes.

Joined Dr. Tsichlis’s laboratory as a Postdoctoral Research Associate in 2002 after he took over the charge of the Director of Molecular Oncology Research Institute at Tufts University Medical Center at Boston, Massachusetts, USA. The focus of his research was to explore the role of Tpl2, an upstream mitogen-activated protein kinase in transducing the signals induced by pro-inflammatory cytokines like TNF-alpha and IL-1beta and in lung and pancreatic inflammation. Altogether, he spent nearly five years at Dr. Tsichlis’s laboratory and worked on the mechanisms underlying the development and progression of inflammatory diseases. 

Research Interests

Salmonella Typhi: pathogenesis and vaccine development

Salmonella Typhi (S. Typhi), the etiologic agent for typhoid poses significant threat to public health, especially in the developing countries. This is contributed by poor knowledge about the disease pathogenesis, treatment failures due to multidrug resistance and unavailability of highly efficacious vaccines. We employed computational approaches coupled with experimental validation to identify novel virulence proteins that promote adhesion and invasion of S. Typhi to intestinal epithelial cells and phagosomal survival within macrophages. In addition, we have developed a protein subunit vaccine that showed significant promise in pre-clinical evaluation. Currently, we are studying the role of stringent response in the persistence of S. Typhi within host macrophages and the mechanisms contributing to the chronic carrier state of S. Typhi and the subsequent development of gall bladder cancer.

Cationic antimicrobial peptides (AMPs): regulation and function

Cationic AMPs are essential components of the innate immune system at the mucosal surfaces. They possess profound immunomodulatory functions in addition to direct microbicidal effects against a wide range of organisms and protect from infectious, autoimmune and neoplastic diseases. Despite significant therapeutic promise, AMPs have not been successfully used for systemic diseases till date, primarily due to problems related to therapeutic formulation and drug delivery. An alternate approach may be to modulate endogenous production of AMPs to cater their varying needs. We have explored several novel mechanisms underlying human cathelicidin production in the intestine and showed that these mechanisms may be exploited to effectively combat enteric infections and inflammations. Additionally, along with our collaborators, we have designed synthetic antimicrobial and immunomodulatory peptides for the treatment of intracellular pathogens and sepsis.

Regulation of intestinal homeostasis

Intestinal homeostasis is critical to maintain normal bacterial flora as well as protection from invading pathogens. Intestinal microflora confers health, while an altered flora (dysbiosis) has been associated with infections, inflammation, metabolic and neurological diseases and cancer. Among numerous factors, short chain fatty acids (SCFAs), especially butyrate derived from fermentation of dietary fibres by the microflora plays a central role in maintaining intestinal homeostasis. We have described novel mechanisms of butyrate functions, which include the regulation of expression of Toll like receptors (TLR5), tumour suppressor genes (caveolin 1) and oncogenes (Syk, PLK1). We have also studied the regulation of immune homeostasis of the intestine by Toll-like receptor signaling and restoration of homeostasis by probiotic bacteria for the treatment of intestinal inflammation.

Bioinformatics:

Computational prediction and network analysis of host-pathogen interactions, molecular modeling and drug designing, immunoinformatics, comparative genomics, multiOMICS data analysis, designing and development of databases and webservers.

Projects

Intramural (ongoing)

  • Host-pathogen interactions in human Salmonella enterica serovar Typhi infections (September, 2014-August, 2017).

Extramural

Ongoing (as principal Investigator)

  • Deciphering the Mechanisms of Invasion by Salmonella Invasins (Funding agency: Department of Science and Technology, Government of India; Duration: 7th November, 2017 - 6th November, 2020)
  • Studies on therapeutic peptides against human Salmonella infections as drugs and vaccine adjuvants (Funding agency: Okayama University, Japan; Duration: 1st April, 2015-31st March, 2020).
  • Studies on immune responses elicited by candidate peptide vaccines and polysaccharide-peptide conjugate vaccines against Salmonella enterica serovars Typhi and Paratyphi infections (Funding agency: Council of Scientific and Industrial Research, Government of India; Duration: 1st January, 2015-31st December, 2017).
  • Study of mechanism of probiotic action in persistent diarrhea in children caused by enteroaggregative E.coli - using a mouse model (Funding agency: Department of Health Research, Government of India; Duration: 1st November, 2014-30th January, 2018).
  • Second phase of Task Force Biomedical Informatics Centre of ICMR (Funding agency: Indian Council of Medical Research, Government of India; Duration: 1st March, 2013-28th February, 2018).

Completed Completed (as principal Investigator)

  • Designing inhibitors of interactions between bacterial Leucine-rich Repeat (LRR)-containing effector proteins with E3 ubiquitin ligase activities and their host targets as novel anti-infective agent (Funding agency: Indian Council of Medical Research (Medical Innovation Fund); Duration: 15th September, 2015 – 14th September, 2017)
  • Development and pre-clinical studies on safety and immunogenicity of novel candidate vaccines against Salmonella enterica serovar Typhi and Paratyphi (Funding agency: Department of Biotechnology, Government of India; Duration: 1st April, 2012-30th November, 2015).
  • Studies on the Regulation of Antimicrobial Peptide Expression and Their Role in Mixed and Opportunistic Infections of the Gut (Funding agency: Okayama University, Japan; Duration: 1st April, 2010-31st March, 2015).
  • Role of Toll-Like and NOD Receptors in Probiotics-Induced Mucosal Toleregenicity (Funding agency: Department of Biotechnology, Government of India; Duration: 1st June, 2011-31st May, 2014).
  • Biomedical Informatics Center of ICMR (Funding agency: Indian Council of Medical Research, Government of India; Duration: 1st July, 2006-30th June, 2012).
  • A Study on Differentiation-induced Regulation of the Immune Response Related Genes in the Intestinal Epithelial Cells (Funding agency: Indian Council of Medical Research, Government of India; Duration: 1st November, 2007-31st October, 2010).
  • Identification and Distribution of HIV-1 Encoded MicroRNAs in North-east Indian Population (Funding agency: Indian Council of Medical Research, Government of India; Duration: 1st June, 2007-31st May, 2010).
  • A Study on the Regulation of Antimicrobial Peptide Expression in the Intestinal Epithelial Cells (Funding agency: Okayama University, Japan; Duration: 1st April, 2007-31st March, 2010).

Ph.D. Students:

Past:

  • Dr Krishnendu Chakraborty, PhD (Currently: Postdoctoral Fellow, Pittsburgh University, USA)
  • Dr Subhamoy Ghosh, PhD (Currently: Postdoctoral Fellow, UCLA, USA)
  • Dr Theeya Nagaraja, PhD (Currently: Assistant Manager, Shantha Biotechnics Limited, Hyderabad)
  • Dr Nirmalya Dasgupta, PhD (Currently: Postdoctoral Fellow, UCSD, USA)
  • Dr Bhupesh Kumar Thakur, PhD
  • Dr Atri Ta, PhD

Present:

  • Ms Pujarini Datta, MSc (SRF: INSPIRE Fellow, DST)
  • Mr Asim Biswas, MSc (SRF: CSIR)
  • Mr Sayan Das, MSc (SRF: CSIR)
  • Ms Rimi Chowdhuri, MSc (Fellow: Okayama University Project)
  • Mr Rahul Shubhra Mondal, M. Tech (Scientist I: ICMR Project)
  • Dr Krishnendu Das, MBBS (JRF, ICMR)
  • Ms Ishani Banerji, MSc (JRF, ICMR)

Project Scientists/Project Fellows/Technical Officer:

Past:

  • Dr Surajit Basak, Scientist II (Currently: Assistant Professor, Tripura University)
  • Dr Paltu Kumar Dhal, Scientist II (Currently: Assistant Professor, Jadavpur University, Kolkata)
  • Dr Swati Bhowmick, DST Woman Scientist
  • Dr Piu Saha, DST Woman Scientist (Currently: Postdoctoral Fellow, University of Pennsylvania, USA).
  • Dr Amita Barik, Scientist II
  • Dr Debdut Naskar (Currently: DST Inspire Faculty, National Institute of Technology, Rourkela)

Present:

  • Dr Ayan Lahiri (Research Associate: CSIR Project)
  • Dr Shreya Dasgupta (ICMR Centenary PDF)
  • Dr Jaidev Joshi (Scientist II, ICMR project)
  • Mr Ananda Pal (Technical Officer)
  • Mr Sanjay Das (laboratory Attendant: ICMR Project)

Awards

  1. Elected Fellow, West Bengal Academy of Science and Technology, 2016.
  2. Fulbright-Nehru Senior Research Fellowship, 2012.
  3. National Bioscience Award for Career Development, 2011 (Department of Biotechnology, Government of India).
  4. Keystone Symposia Global Health Travel Award for London, UK, 2016 - Sayan Das, PhD student.
  5. Keystone Symposia Global Health Travel Award for London, UK, 2016 - Rimi Chowdhury, Ph.D. Student.
  6. Travel Award from the Department of Biotechnology, India to attend the “The EMBO Meeting” at Mannheim, Germany, 2016 - Sayan Das, PhD student.
  7. Travel Award from the Department of Biotechnology, India to attend the “The EMBO Meeting” at Mannheim, Germany, 2016 - Rimi Chowdhury, Ph.D. student.
  8. Travel Award from Wellcome Trust to attend the “Protein Interactions and Networks Workshop” At Hinxton, UK, 2016 - Rimi Chowdhury, Ph.D. student.
  9. Best Poster Award at the 8th Indo Global Summit on Vaccines, Therapeutics and Healthcare, organized by OMICS International at Hyderabad, India, 2015 - Sayan Das, PhD student.
  10. BioAsia Innovation Award, 2015 – Rahul Shubhra Mondal, PhD student.
  11. Best Poster Award at the 2nd Annual conference of the Probiotic Association of India, 2014 – Piu Saha, Postdoctoral Fellow.
  12. Travel Award from DST, India to attend the 5th ACM Conference at California, USA, 2014 – Rahul Shubhra Mondal, PhD student.
  13. Young Investigator Award at the Yakult (India) Probiotics Meeting, 2014 - Bhupesh Kumar Thakur, PhD student.
  14. Best Poster Award at the International Conference on Host-Pathogen Interaction at NIAB, Hyderabad, 2014 - Theeya Nagaraja, PhD student.
  15. Best Poster Award at the Conference on Recent Advances in Computational Drug Design at Indian Institute of Science, Bangalore, 2013 - Rahul Shubhra Mondal, PhD student.
  16. Best Poster Award at IMMUNOCON, 2013 - Piu Saha, Postdoctoral Fellow.
  17. Best Poster Award at the 1st Annual conference of the Probiotic Association of India, 2012 - Bhupesh Kumar Thakur, PhD student.
  18. Prof. Awtar Krishnan Prize for excellence in Flowcytometry at NCBS, Bangalore, 2012 – Bhupesh Kumar Thakur, PhD student.
  19. 19. Cytometrist of the Year Award at the 5th Annual meeting of the Cytometriy Society, India, 2011 – Piu Saha, Postdoctoral Fellow.
  20. 20. Travel Award from DST, India to attend the Keystone Symposia at Trinity College, Dublin, Ireland, 2010 - Krishnendu Chakraborty, PhD student.
  21. 21. Best Poster Award at the IMMUNOCON 2007 - Krishnendu Chakraborty, PhD student

Memberships

  • American Society of microbiology (contributing member)
  • Probiotic Association of India (life member)
  • Molecular Immunology Forum (nominated member)
  • Society of Biological Chemists, India (life member)
  • Indian Science Congress Association (life member)

Publications

For complete bibliography, please see: http://1.usa.gov/21gp5Ff

2017

  1. Chowdhury R, H Ilyas, A Ghosh, H Ali, A Ghorai, A Midya, NR Jana, S Das, A. Bhunia. Multivalent Gold nanoparticle–Peptide Conjugates for Targeting Intracellular Bacterial Infections. Nanoscale. 2017 Sep 28;9(37):14074-14093. Pubmed
  2. Jana S, D Patel, S Patel, K Upadhyay, J Thadani, R Mandal, S Das, R Devkar. Anthocyanin rich extract of Brassica oleracea L. alleviates experimentally induced myocardial infarction. PLoS One. 2017 Aug 1;12(8):e0182137 Pubmed
  3. Das S, R Chowdhury, S Ghosh, S Das. A recombinant protein of Salmonella Typhi induces humoral and cell-mediated immune responses including memory responses. Vaccine. 2017 Aug 16;35(35 Pt B):4523-4531. Pubmed
  4. Ta A, BK Thakur, P Dutta, R Sinha, H Koley, S Das. Double-stranded RNA induces cathelicidin expression in the intestinal epithelial cells through phosphatidylinositol 3-kinase-protein kinase Cζ-Sp1 pathway and ameliorates shigellosis in mice. Cell Signal. 2017 Jul; 35:140-153 Pubmed
  5. Sinha R, DR Howlader, A Ta, S Mitra, S Das, H Koley. Retinoic acid pre-treatment down regulates V. cholerae outer membrane vesicles induced acute inflammation and enhances mucosal immunity. Vaccine. 2017 Jun 16; 35(28):3534-3547. Pubmed
  6. Mandal RS, S Panda, S Das. In silico prediction of drug resistance due to S247R mutation of Influenza H1N1 neuraminidase protein. J Biomol Struct Dyn. 2017 Apr 10:1-15. Pubmed
  7. Barman RK, A Mukhopadhyay, S Das. An improved method for identification of small non-coding RNAs in bacteria using support vector machine. Sci Rep. 2017 Apr 6; 7:46070. Pubmed
  8. Barman RK, A Mukhopadhyay, S Das. An improved method for identification of small non-coding RNAs in bacteria using support vector machine. Sci Rep. 2017 Apr 6; 7:46070. Pubmed
  9. Dasgupta N, BK Thakur, A Ta, S Das, G Banik, S Das. Polo-like kinase 1 expression is suppressed by CCAAT/enhancer-binding protein α to mediate colon carcinoma cell differentiation and apoptosis. Biochim Biophys Acta. 2017 Jul; 1861(7):1777-1787. Pubmed
  10. Dutta P, A. Ta, B. K. Thakur, N. Dasgupta, S Das. Biphasic Ccl20 regulation by Toll-like receptor 9 through the activation of ERK-AP-1 and non-canonical NF-κB signaling pathways. Biochim Biophys Acta. 2017 Jan; 1861(1 Pt A):3365-3377. Pubmed
  11. 10. Dasgupta N., B. K. Thakur, A. Ta, P. Dutta, and S. Das. Suppression of Spleen Tyrosine Kinase (Syk) by Histone Deacetylation Promotes, Whereas BAY61-3606, a Synthetic Syk Inhibitor Abrogates Colonocyte Apoptosis by ERK Activation. J Cell Biochem. 2017 Jan; 118(1):191-203. Pubmed

2016

  1. Mandal RS, A. Ta, R. Sinha, N. Theeya, A. Ghosh, M. Tasneem, A. Bhunia, H. Koley, S. Das. 2016. Ribavirin suppresses bacterial virulence by targeting LysR-type transcriptional regulators. Sci Rep. 6:39454. Pubmed
  2. Thakur B. K., N. Dasgupta, A. Ta, and S. Das. 2016. Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms. Nucleic Acids Res. 2016 Jul 8;44(12):5658-72 Pubmed
  3. Thakur B. K., P. Saha, G. Banik, D. R. Saha, S. Grover, V. K. Batish, and S. Das. 2016. Live and heat-killed probiotic Lactobacillus casei Lbs2 protects from experimental colitis through Toll-like receptor 2-dependent induction of T-regulatory response. Int Immunopharmacol. 36:39-50 Pubmed
  4. Parida S, I. Pal, A. Parekh, B. Thakur, R. Bharti, S. Das, and M. Mandal. 2016. GW627368X inhibits proliferation and induces apoptosis in cervical cancer by interfering with EP4/EGFR interactive signaling. Cell Death Dis.;7:e2154 Pubmed
  5. Saha P, C. Manna, S. Das, and M. Ghosh. 2016. Antibiotic binding of STY3178, a yfdX protein from Salmonella Typhi. Sci Rep. 2016 Feb 19;6:21305 Pubmed
  6. Datta P, S. Das. 2016. Mammalian antimicrobial peptides: promising therapeutic targets against infection and chronic inflammation. Curr. Top. Med. Chem. 16(1):99-129. Pubmed

2015

  1. Das S and B. K. Thakur. 2015. Mucosal immune system of the respiratory tract: regulation of tolerance and immune response. The Pulmo-Face XV(2): 61-70.
  2. Mandal R. S and S. Das. In silico approach towards identification of potential inhibitors of Helicobacter pyloriDapE. J BiomolStructDyn.2015 Jul.33(7):1460-73 Pubmed
  3. Dasgupta N, B. K. Thakur, A. Ta A and S. Das. 2015. Caveolin-1 is transcribed from a hypermethylated promoter to mediate colonocyte differentiation and apoptosis.Exp Cell Res. 2015 Jun 10;334(2):323-36 Pubmed
  4. Banerjee R, S.Das, S.Basak. Similarity of currently circulating H1N1 virus with the 2009 pandemic clone: Viability of an imminent pandemic. Infection, Genetics and Evolution. 2015 Jun; 32:107-112. Pubmed
  5. Chowdhury R, R. S. Mandal, A. Ta and S. Das. An AIL family protein promotes Type Three Secretion System-1 independent invasion and pathogenesis of Salmonella entericaserovar Typhi. Cell Microbiol. 2015 Apr. 17(4):486-503 Pubmed
  6. Nagaraja T, A. Ta, S. Das, R. S. Mandal, O. Chakrabarti, S. Chakrabarti, A. N. Ghosh and S. Das. An Inducible and Secreted Eukaryotic-like Serine/Threonine Kinase of Salmonella Typhi Promotes Intracellular Survival and Pathogenesis. 2015. Infect Immun. 83(2):522-33 Pubmed
  7. Barman R. K., T. Jana, S. Das, S. Saha. 2015. Prediction of intra-species protein-protein interactions in enteropathogens facilitating systems biology study. PLoS One. 10(12):e0145648. Pubmed
  8. Mandal R. S., S. Saha, S. Das. 2015. Metagenomic surveys of gut microbiota. Genomics, Proteomics Bioinformatics 13(3):148-158. Pubmed

2014

  1. Bhowmick S, M. Malar, A. Das, B. K. Thakur, P. Saha, S. Das, H. M. Rashmi, V. K. Batish, S. Grover and S. Tripathy. 2014. Draft Genome sequence of Lactobacillus casei Lbs2. Genome Announc.2(6): e01326-14 Pubmed
  2. Barman RK, S. Saha, S Das. 2014. Prediction of interactions between viral and host proteins using supervised machine learning methods. PLoS ONE. 9(11):e112034 Pubmed
  3. Dhal P. K, R. K Barman, S. Saha and S. Das. 2014. Dynamic Modularity of Host Protein Interaction Networks in Salmonella Typhi Infection. PLoS One. 9(8):e104911 Pubmed
  4. Bhattacherjee A, R.S. Mandal, S. Das, S. Kundu. 2014. Sequence and 3D structure based analysis of TNT degrading proteins in Arabidopsis thaliana. J Mol Model. 20(3):2174. Pubmed

2013

  1. Rajendra Kumar Labala, Santasabuj Das, and Surajit Basak 2013. ASRDb: A comprehensive resource for archaeal stress response genes. Bioinformation. 9: 650-655. Pubmed

2012

  1. Dasgupta A., R. Banerjee, S. Das and S. Basak. 2012. Evolutionary perspective on the origin of Haitian cholera outbreak strain. J Biomol Struct Dyn. 30: 338-46. Pubmed
  2. Banerjee R, A. Roy, F. Ahmad, Das S, S. Basak. 2012. Evolutionary patterning of hemagglutinin gene sequence of 2009 H1N1 pandemic. J Biomol Struct Dyn. 29: 733-742. Pubmed

2011

  1. Ghosh S., K. Chakraborty, T. Nagaraja, S. Basak, H. Koley, S. Dutta, U. Mitra and S. Das. 2011. An adhesion protein of Salmonella enterica serovar Typhi is required for pathogenesis and potential target for vaccine development.
    Proc Natl Acad Sci U S A. 108: 3348-3353. Pubmed

2010

  1. Roy N, S. Barman, A. Ghosh, A. Pal, K. Chakraborty, S. Das, D. R. Saha, S. Yamasaki and H. Koley. 2010. Immunogenicity and protective efficacy of Vibrio cholerae outer membrane vesicles in rabbit model. FEMS Immunol Med Microbiol. 60: 18-27. Pubmed
  2. Bhadra R. K., S. Das and G. B. Nair. 2010. Immunological basis for Immunization: Cholera. WHO/IVB/ISBN 978 92 4 159974 0, pp.1-31. Pubmed

2009

  1. Sinha, N. K., A. Roy, B. Das, S. Das and S. Basak. 2009. Evolutionary complexities of swine flu H1N1 gene sequences of 2009. Biochem Biophys Res Commun. 390: 349-51. Pubmed
  2. Chakraborty, K., P. C. Maity, A. K. Sil, Y. Takeda and S. Das. 2009. cAMP stringently regulates human cathelicidin antimicrobial peptide expression in the mucosal epithelial cells by activating cAMP-response element-binding ptotrin, AP-1, and Inducible cAMP early repressor. J Biol Chem. 284:21818-21827. Pubmed
  3. Basak, S., R. Banerjee, I. Mukherjee, S. Das. 2009. Influence of domain architecture and codon usage pattern on the evolution of virulence factors of Vibrio cholerae. Biochem Biophys Res Commun. 379: 803-805. Pubmed

2008

  1. Basak, S., I. Mukherjee, M. Choudhury and S. Das. 2008. Unusual codon usage bias in low expression genes of Vibrio cholerae. Bioinformation. 3: 213-217. Pubmed
  2. Chakraborty, K., S. Ghosh, H. Kole, A. K. Mukhopadhyay, T. Ramamurthy, D. R. Saha, D. Mukhopadhyay, S. Roychowdhury, T. Hamabata, Y. Takeda and S. Das. 2008. Bacterial exotoxins downregulate cathelicidin (hCAP18/LL37) and human defensin 1 (HBD-1) expression in the intestinal epithelial cells. Cell Microbiol. 10: 2520-2537. Pubmed
  3. Chakraborty, K., S. Ghosh, H. Kole, A. K. Mukhopadhyay, T. Ramamurthy, D. R. Saha, D. Mukhopadhyay, S. Roychowdhury, T. Hamabata, Y. Takeda and S. Das. 2008. Bacterial exotoxins downregulate cathelicidin (hCAP18/LL37) and human defensin 1 (HBD-1) expression in the intestinal epithelial cells. 2008. (In Press). Pubmed

2007

  1. Van Acker, G. J., G. Perides, E. R. Weiss, S. Das, P. N. Tsichlis and M. L. Steer. 2007. Tumor progression locus-2 is a critical regulator of pancreatic and lung inflammation during acute pancreatitis. J. Biol Chem. 282: 22140-9. Pubmed

2006

  1. Ghosh, A., D. R. Saha, K. M. Hoque, M. Asakuna, S. Yamazaki, H. Koley, S. Das, M. K. Chakraborty and A. Pal. 2006. Enterotoxigenicity of 45kDa matured and 35kDa processed forms of hemagglutinin protease purified from a cholera toxin gene negative Vibrio cholerae non-O1non-O139 strain. Infect Immun. 74: 2937-46. Pubmed
  2. Eliopoulos, A. G., S. Das and P. N. Tsichlis. 2006. The tyrosine kinase Syk regulates TPL2 activation signals. J. Biol Chem. 281: 1371-80. Pubmed

2005

  1. Das, S., J. Cho, I. Lambertz, M. A. Kelliher, A. G. Eliopoulos, K. Du and P. N. Tsichlis. 2005. Tpl2/Cot Signals Activate ERK, JNK, and NF-?B in a Cell-type and Stimulus-specific Manner. J. Biol Chem. 280: 23748-57. Pubmed

2002

  1. Das, S., J. H. Lin, J. Papamatheakis, Y. Sykulev and P. N. Tsichlis. 2002. Differential splicing generates Tvl-1/RFXANK isoforms with different functions. J. Biol Chem. 277: 45172-80. Pubmed

Books/ Book Chapters/ Training Modules:

  1. Mandal RS, S. Das. 2017. In Silico Approaches Toward Combating Antibiotic Resistance. In Arora G, sajid A, Kalia VC (eds), Drug Resistance in Bacteria, Fungi, Malaria, and Cancer. Springer, pp.577-593.
  2. Dutta P and S Das. 2015. Antimicrobial peptides and infectious Diseases. In Mendez-Vilas A (ed), The Battle against Microbial Pathogenesis: Basic Science and Educational Programmes, 5th series. Badazgoz Spain, Formatex Research Centre.
  3. 3. Bhadra R. K., S. Das and G. B. Nair. 2010. Immunological basis for Immunization: Cholera. WHO/IVB/ISBN 978 92 4 159974 0, pp.1-31.

Patents Granted

  1. Das S, Ghosh S. A novel salmonella typhi protein as subunit vaccine. (Patent No. 283894; Pub Date: 09.09.2011).

  2. Das S, Bhunia A. A peptide to neutralize lipopolysaccharide molecule. (Pub No. WO 2016 132377 A1; Pub Date: 25/08/2016).

  3. Koley H, Mitra S, Das S, Chakrabarti MK. A multi-serotype outer membrane vesicles (momv) of Shigellae as a novel candidate vaccine. (Pub No. WO/2014/192031; Pub Date: 04.12.2014).

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