I, Dr. Provash Chandra Sadhukhan, Scientist D, was born on 16th January, 1967 and joined ICMR Virus Unit, Kolkata on 28th January 2005 as Scientist B. I did B.Sc in Chemistry from Scottish Church College (Calcutta University) in 1988; M.Sc. in Biochemistry from Calcutta University in 1990; and Ph.D. in Biochemistry from the Calcutta University, specialization in microbiology with special emphasis on microbial detoxification of mercury in fish by mercury resistant aquatic bacteria. I joined Learner Research Institute, Cleveland Clinic Foundation, USA as a postdoctoral Research Fellow in August, 1998, where I studied cell signaling in cancer cells, specially Interferon and NF-kB signaling in bladder and kidney cancer cells. I also studied viral gene therapy on cancer cells, effect of natural products on cancer cells and their role in modulation of cellular signaling pathways and cancer cell growth.
|Name :||Dr. Provash Chandra Sadhukhan|
|Designation :||Scientist D|
|Date of joining ICMR :||28th January, 2005|
|Date of joining present post :||1st September, 2014|
|Discipline :||Virology, Molecular Biology|
|Division :||Virus Laboratory|
|Specialization :||Viral Disease|
|Email :||Sadhukhan.firstname.lastname@example.org , email@example.com|
|Academic Qualification :||M.Sc., Ph.D.|
|Graduation||B.Sc. Chemistry (Hons.), Calcutta University|
|Post-Graduation||M.Sc. Biochemistry, Calcutta University|
|Doctoral||Biochemistry (area Microbiology), Calcutta University|
I received my M.Sc. in Biochemistry from Calcutta University in 1990 and Ph.D. in Biochemistry from the same Department of Calcutta University. My major study area during doctoral work was in microbiology with special emphasis on microbial detoxification of mercury in fresh water fish by mercury resistant aquatic bacteria. I gained experience in cell signaling in cancer cells, specially IFN and NF-kB signaling in bladder and kidney cancer cells as a postdoctoral Research Fellow in Cleveland Clinic Foundation, USA. I also have experience in viral gene therapy, effect of natural products on cancer cells and their role in modulation of cellular signaling pathways and cancer cell growth. I joined ICMR Virus Unit, Kolkata in January 2005 as Scientist B, where I started my research area on hepatitis C and viral co-infections in HIV/AIDS patients. Thereafter, I focused mainly on RNA virus, specially on HCV and dengue virus genome characterization and the role of different viral proteins in the modulation of host immune system.
This Lab works in the field of infectious diseases with special emphasis on RNA viruses, more specifically flavivurses. Our research platform is based on Hepatitis C and Dengue virus from eastern and north eastern region of India and an exhaustive interface between clinical sciences, experimental biology and bio-informatics. The major focuses of this group on the molecular epidemiology of the local circulating strains and their migration pattern, rapid detection of emerging viruses by applying latest technology as a part of translation research. Host-virus interaction and immune responses by the host including modulation of cytokines and chemokines expression to understand the molecular mechanisms underlying the immune responses and immune evasion mechanisms of the viruses. Cloning and expression of viral envelope glycoprotein, protease and RNA- dependent RNA polymerase proteins are of special interest for therapeutic intervention. We practice molecular biology, reverse genetics, cell biology techniques and computer modelling in our regular day to day research work.