Field of Research:
Research focus is on the development of novel vaccine candidate
against enteric pathogens like Vibrio cholerae,
Shigella, Salmonella, Escherichia coli, and
Campylobacter for the livestock and human.
Laboratory has identified a number of potential vaccine candidates like outer membrane vesicles, heat killed bacteria, live attenuated bacteria, chitosan-alginate nanoparticle.
Special expertise on outer membrane vesicles based studies on various animal models, like Mouse, Rat, Guinea pig, Rabbit, Chicken and Zebra fish.
Long path programme of the laboratory is to develop a single vaccine candidate against all enteric pathogens.
In 1992, after completion of Master degree in Human Physiology from Dept. of Physiology, University College of Science & Technology, Calcutta University, he joined Division of Bacteriology, National Institute of Cholera and Enteric Diseases (NICED), an integral Institute of the Indian Council of Medical Research and a WHO Collaborating Centre for Research and Training in Diarrhoeal Diseases, Kolkata, India, for Ph. D. degree under supervision of Dr. GB Nair. In 1996, he joined as Associate Professor in Dept. of Physiology, College of Medical Sciences-Nepal, where he devoted himself entirely in teaching medical students. Meanwhile, Dr. Koley got an opportunity for Post-Doctoral research in the laboratory of Prof Dipak K Sarkar, Dept Animal Sciences, Rutgers - The State University of New Jersey, New Brunswick, USA. After completion of one year in Rutgers University, Dr. Koley moved to Boston, joined Gastroenterology Section of Harvard Medical School, as Research Associate and worked there on "Molecular mechanism of Barrett's oesophagus and to identify therapeutic target for Adenocarcinoma" under leadership of Prof. R K Goyal, renowned gastroenterologist.
Published 70 original papers and 40 abstracts in his credit.
Secured patent for a process for the preparation of Cholera Vaccine-VA1.3 (European Patent Office; Patent No.- 97309957.5-2105 on 19/05/98) in pre-doctoral research in NICED
Received Young Scientist Award in IUPS International Congress, Christchurch, New Zealand, August 2001.
Awarded Oration Lecture: "Dr. (Mrs.) Chitralekha Mukherjee Memorial Oration-2010" and given lecture at St. John's Medical College, Bangalore on 16th December 2010
Recently developed Shigella Vaccine and applied patent through Indian council of Medical Research, New Delhi. Patent application for: "A multiple outer membrane vesicles (MOMV) of Shigellae as a Novel Candidate vaccine" ICMR New Delhi. (Patent application no. 1652/Del/2013 dated 31.05.2013)
International patent application: PCT patent application titled ‘A Multi-Serotype Outer Membrane Vesicles (MOMV) of shigellae as a novel candidate vaccine' (PCT/IN2014/000369).
Patent application for: "Alginate chitosan Nano formulation of
Omp-A, a Shigella protein subunit vaccine" ICMR New Delhi.
(Patent application # 201611015219/ IPR/NICED/OmpA/329 June,
Invited special lecture at "Asian Society of Diarrhoeal Disease and Nutrition" conference (ASCODD) at Kochi between October 30,2017 to November 1, 2017.
Invited Lecture on "Shigella Vaccine" Occasion of MSD-Hilleman
Laboratory Science day workshop on 2nd Nov 2017 at Imperial
Hotel, New Delhi.
1992-96 Joined as Junior Research Fellow worked on
isolation, characterizations of clinical and
environmental enteric organism and completed of Ph. D.
degree from University of Calcutta.
1996-2001, joined as Associate Professor in Dept. Physiology, College of Medical Sciences-Nepal, where he devoted entire heartily in teaching medical
2001-2002 worked on Foetal Alcohol different modelsaspost-doctoral research associate at Dept of Animal Sciences, Rutgers -The State University of New Jersey, New Brunswick, USA.
2002-2004 joined Gastroenterology Section, Harvard Medical School as Research Associate and worked there on "Molecular mechanism of Barrett's oesophagus and to identify therapeutic target for Adenocarcinoma"
2004 - Still date: Joined back to Division of Bacteriology,National Institute of Cholera and Enteric Diseases (NICED), Kolkata, devotedly working on development of a single vaccine protect against entire circulating enteric organisms.
Research interest is to understand signal transduction pathways in immune and inflammatory cells during diarrhoea and also to study the nature of protection against diarrhoeal pathogens like Vibrio cholerae, Shigella, Diarrhoeagenic E Coli, Typhoidal and non Typhoidalsalmonellasp, Campylobactersp in different animal models.