The Division of Bacteriology has
multifarious functions that include isolation and identification of
enteric bacteria from stool specimens collected from the
hospital/community through systematic surveillance, vaccine trial
studies, confirmation and serotyping of enteric bacteria such as
Vibrio parahaemolyticus ,toxigenic V. cholerae, diarrhoeagenic
Escherichia coli, Shigella sent by other institutions, and
outbreak investigations to detect the possible etiological agents.
The basic research components include molecular typing of bacterial
strains, detection of virulence genes, antimicrobial susceptibility
patterns, detection of resistance mechanisms and novel toxins.
Several new molecular/immunological based detection techniques have
also been developed and evaluated at the NICED. The recently emerged
hybrid El Tor variant strains of V. cholerae has been
characterized and tracking of its spread in different states of
India has also been made.
Antisera against V. cholerae O1 and O139 were produced and
being supplied to different Institutions for research purpose.
Helicobacter pylori strains collected from duodenal ulcer patients
and asymptomatic individuals were also extensively characterized at
molecular level. This Division has large collection of well
characterized bacterial strains and standard strains. Some of the
ongoing research activities are supported by the ICMR. In addition,
multicentric projects are funded by the International Vaccine
Institute, Korea; Melinda and Gates Research Foundation, USA;
Ministry Health, Labour and Family Welfare, Japan; and Okayama
University, Japan. Works related with pulsed-field gel
electrophoresis for molecular typing of V. cholerae, V.
parahaemolyticus are part of the PulseNet Asia-Pacific research
activity. Several training programmes on conventional microbiology
and molecular typing were organized at the national and
international levels with the support from the WHO/Japan
International Cooperation Agency.