ANNUAL REPORT 2005-2006

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		Annual Report 2005-06

 

	Particulars	Page No.
1.	Study On Hospital Surveillance.	10
1.1.	Hospital based Surveillance system for diarrhoeal diseases.	10
2.	Community Based Studies.	12
2.1.	Acute lower respiretory tract infection ( ALRI ) and diarrhoeal in rural children below two years in relation to feeding practices with particular reference to breast feeding : A community based study.	12
2.2.	Epidemiology of typhoid fever in a rural and urban slum community of West Bengal.	12
2.3.	Identifying environmental risk factors for endemic diarrhoeal  diseases in West Bengal, India : a remote sensing - geographic information system ( GIS ) approach.	13
3.	Clinical Studies.	16
3.1.	Evaluation of comparative efficacy of Cefuroxime axetil and Tetracycline in the treatment of cholera in adults.	16
3.2.	Impact of Lactobacillus (Lactic acid bacteria) in children with acute watery diarrhoea.	16
4.	Studies on Vibrio cholerae.	18
4.1.	Molecular epidemiology of cholera in india.	18
4.2.	Vibriocidal assay on rough vibrio cholerae strains with acute and convalescent sera collected from cholera patients and implication of gene(s) for the rough phenotype.	19
4.3.	Studies on the structure-function relationship of vibrio cholerae hemolysin (HIy A).	20
4.4.	Exploring the mechanism of the immun omodulatory functions of cholerae toxin.	21
4.5.	Enterotoxigenicity of 45-kDa matured and 35-kDa processed forms of hemagglutinin protease purified from a cholera toxin gene negative vibrio cholerae  non-O1 , non -O139 strain.	25
5.	Studies on vibrio cholerae phages.	26
5.1.	Nationwide screening of phage types of V.cholerae O1 biotype EITor.	26
5.2.	Molecular analysis of vibrio cholerae bacteriophages : cloning and sequencing of phage DNA.	26
6.	Studies on shigella species.	28
6.1.	Molecular characterization of multi-drug resistant shigella flexneri In Kolkata.	28
6.2.	Antigenic recognitation of shigella dysenteriae outer membrane proteins using human convalescent sera and to evaluate their role in cell-mediated immune response in shigellois.	29
6.3.	Porin Induced Polarization of Peritoneal Macrophage and Activation of  T cells for Th 1/Th 2/ Response.	30
7.	Studies on Escherichia coli.	31
7.1.	Studies on the binding of Escherichia coli heat-stable enterotoxin to the intestinal epithelial cells and brush border membranes of different animals.	31
7.2.	Electron microscopic study of ultra structures associated with Intestinal cell adherence of enteroaggregative Escherichia coli isolated from acute hospitalized diarrhea cases and healthy control children from Kolkata.	32
7.3.	Detection and characterization of different colonization factors for molecular typing of Enterotoxigenic Escherichia coli.	32
8.	Studies on Helicobacter pylori.	35
8.1.	Characterization of the cag pathogenicity island of  Helicobacter pylori isolated in Kolkata with reference to interleukin-8 secretion.	35
8.2.	Correlation of histology with genotypes of Helicobacter Pylori isolated from cases of Pepticulcer, Non ulcer dyspepsia, Gastric carcinoma and Lymphoma.	36
9.	Studies on other bacterial pathogen.	38
9.1.	Mode of action of yersinia enterocolitica heat stable enterotoxin (YSTa) in rat intestinal epithelial cell.	38
10.	Studies on Diarrhoeagenic Parasites.	39
10.1.	Cloning and Characterization of Collagenase genes of Entamoeba histolytica.	39
11.	Studies on Viral Pathogens.	41
11.1.	Molecular characterization of a porcine group A rota virus strains in Eastern India.	41
11.2.	Genomic diversity of Group A rota virus strains in Eastern India.	41
11.3.	Genogrouping rotaviruses of human and animal origin in India.	42
11.4.	Molecular characterization of human Caliciviruses, Astroviruses and Picobirnaviruses.	42
12.	Studies on HIV/AIDS.	47
12.1.	Distribution of HIV-1 subtypes on the basis of gag gene.	47
12.2.	HIV and Sexually transmitted infections in sex workers of West Bengal.	50
12.3.	A study on HIV and HCV infection among injecting drug users of Darjeeling District, West Bengal.	51
13.	Epidemic Investigations.	52
13.1.	Investigation of outbreak of Dengue, Leptospirosis and gastroenteritis.	52
13.2.	Report of diarrhoeal outbreak in different wards of Garulia, North 24-Parganas, West Bengal.	52
13.3.	Investigation on Jaundice outbreak at Durgapur, West Bengal.	55
14.	Activities of Traning and Extension Division.	56
14.1.	Phase IIA of VA1.3 candidate Cholera vaccine DBT Meeting.	56
14.2.	Two training Programmes for German Doctors on Tropical and Travel Medicine Jointly organized by Jadavpur University.	56
14.3.	National Technology Day Celebration.	56
14.4.	Work shops on water Quality Monitoring held at Siliguri, Burdwan, Kolkata, Malda and Midnapore.	56
14.5.	3rd Country JICA-NICED Training Programme on Molecular Epidemiology of Diarrhoeal Diseases with special reference to cholera organized by NICRD and Japanese International Cooperation Agency (JICA).	57
14.6.	JICA-NICED Domestic Training Programme on Molecular Epidemiology of Diarrhoeal Diseases with special reference cholera organized by NICED and Japanese International Cooperation Agency (JICA).	58
14.7.	INDO-US Workshop on diarrhoea protogoans Parasites-New chalanges on the era of HIV/AIDS.	59
14.8.	Training Programme of informedia.co .in on biomedical collection.	59
14.9.	Indo-US Workshop on Water Quality Monitoring.	60
15.	JICA - NICED Collaborative Project.	61
16.	IVI-NICED Collaborative Project.	68
16.1.	Randomised controlled evaluation of protection by Vi  polysaccharide vaccine against typhoid fever in Eastern Kolkata.	68
16.2.	Socio-behavioral and economics studies on typhoid fever and cholera.	69
16.3.	A randomized controlled trail of the bivalent killed whole cell oral cholera vaccine in Eastern Kolkata,  West Bengal, India.	69
17.	Scientific Conference/Seminar/Meeting Attended By The Scientists/Research Fellows/Stuff.	71
18.	Training/Awards received by The Scientists/Research Fellows/Staff.	78
19.	Others activities of the Scientists.	79
20.	List of Publications.	80
21.	Committees of the Institute.	86
22.	List of the Staff.	90